this looks like a common problem. Try re-installing chrome and see if that fixes it. You might need to reboot after the re-install.
The Windows Updates seem to be a chronic source of problems. I uninstalled a recent one and (one of) my problems went away.
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Using Chrome as my primary browser, following the most recent Microsoft Windows10 update, I've lost the ability to access Bookmark Manager, via the ctrl+shift+o keyboard shortcut.
This had happened previously, but, this time I'm unable to recall how I restored the shortcut; and my hunting has yet to yield a solution.
Any help would be appreciated.
Thanks in advance,
TomR